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KMID : 0356420080260020069
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Journal of Korean Andrology
2008 Volume.26 No. 2 p.69 ~ p.73
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Therapy with Human Chorionic Gonadotropin and Human Menopausal Gonadotropin in Men with Hypogonadotropic Hypogonadism
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Kim Sang-Deuk
Kim Myung-Ki
Park Jong-Kwan
Park Jong-Kwan
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Abstract
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Purpose: Hypogonadotropic hypogonadism (HH) is an uncommon cause of virilization and male infertility. We evaluated the effect of the combination therapy with human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) in patients with HH.
Materials and Methods: Between May 2000 and April 2007, we evaluated 15patients with HH. Testicular volume,
serum luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, and semen analysis were consecutively monitored at 6, 12, 24, 36 and 48 months after hCG/hMG combination therapy. Statistical analysis was performed by Paired Student’s t-test.
Results: Testicular volume showed a time-dependent increase in all patients who received hCG/hMG combination therapy (p<0.01). At 12 months, 12 patients showed and were significant improvement in FSH (1.6±0.97mIU/ml, p<0.033) and in serum total testosterone (71±2.73ng/ml, p=0.003), respectively. During hCG/hMG combination therapy, semen volume, sperm number, sperm motility, and sperm morphology were improved. However, there was no significant change in LH levels.
Conclusions: Our experience in the management of the patients with HH suggests that hCG/hMG combination therapy might be effective in improving the sperm volume, sperm number, sperm motility, sperm morphology, plasma
FSH, total testosterone level, and testicular volume. Thus hCG/hMG therapy seems a better choice in the patients with
HH who want pregnancy.
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KEYWORD
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Hypogonadotropichypogonadism(HH), Humanchorionicgonadotropin(hCG)
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